PF3D7_1308700

Genome location: Pf3D7_13_v3:401,356..404,582(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.05	0.98
Trophozoite	not expressed	0.46	0.72
Schizont	not expressed	0.39	0.75
Gametocyte	not expressed	0.52	0.71

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1308700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.31 | MFS: -2.75 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEM7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_108345

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	18	20	22
disruptive	22	78	49	106
missense	14	68	47	89

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	45	17	18
disruptive	33	178	64	159
missense	21	149	54	100

PlasmoDB Total SNPs: 225

Non-coding: 39 | Synonymous: 105 | Nonsynonymous: 81 | Stop Codon: 0

Protein Information

Protein Length: 607 | Molecular Weight (kDa): 72.5

UniProt ID(s): Q8IEM7

PDB ID(s): None

Isoelectric Point: 5.39

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A