About Gene List

PF3D7_1308800 (INT)

Genome location: Pf3D7_13_v3:403,496..407,163(-)

Genome classification: Core

Function and Localization

Product Description: tyrosine recombinase

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring possibly expressed 0.12 0.94
Trophozoite expressed 0.90 0.54
Schizont expressed 0.53 0.71
Gametocyte expressed 0.64 0.65

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1308800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.21 | MFS: -2.757 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H5A8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_152637

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 6 43 20 45
disruptive 6 59 25 79
missense 6 51 25 73

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 8 78 25 47
disruptive 14 125 65 111
missense 8 109 57 82

PlasmoDB Total SNPs: 250

Non-coding: 214 | Synonymous: 27 | Nonsynonymous: 9 | Stop Codon: 0

Protein Information

Protein Length: 490 | Molecular Weight (kDa): 57.747

UniProt ID(s): C0H5A8

PDB ID(s): None

Isoelectric Point: 10.21

Protein Domain Annotations:

Source Family ID Description
InterPro IPR002104 Integrase, catalytic domain
InterPro IPR011010 DNA breaking-rejoining enzyme, catalytic core
PFam PF00589 Integrase, catalytic domain
Superfamily SSF56349 DNA breaking-rejoining enzyme, catalytic core

Associated Publications

PMID Title Authors DOI/Link
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
22144892 A systematic screen to discover and analyze apicoplast proteins identifies aconserved and essential protein import factor. Sheiner L, Demerly JL, ..., Striepen B 10.1371/journal.ppat.1002392
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895