Product Description: mRNA-decapping enzyme 2, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005634 | nucleus |
| Function | GO:0016787 | hydrolase activity |
| Function | GO:0050072 | m7G(5')pppN diphosphatase activity |
| Process | GO:0000290 | deadenylation-dependent decapping of nuclear-transcribed mRNA |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.60 | 0.72 |
| Trophozoite | expressed | 0.96 | 0.50 |
| Schizont | expressed | 0.34 | 0.80 |
| Gametocyte | expressed | 0.94 | 0.50 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1308900
Resistome Missense Mutations: Q192H
Resistome Compounds with Missense Mutations: MMV019017
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.033 | #Insertions: 3
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IEM5
"Best" AlphaFill ligand hit: B4P (bis(adenosine)-5'-tetraphosphate, Local RMSD=0.38) with 3I7V (Global RMSD=6.64)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102623
Most Similar Human Ortholog: A0A6Q8PGL6
TM-align score: 0.83 | RMSD: 2.48
Seq Identity: 0.30 | Length: 152 / 1173
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000172795 | decapping mRNA 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 22 | 98 | 53 | 101 |
| disruptive | 65 | 237 | 111 | 283 |
| missense | 42 | 213 | 102 | 236 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 34 | 184 | 64 | 93 |
| disruptive | 124 | 475 | 192 | 376 |
| missense | 78 | 415 | 161 | 244 |
PlasmoDB Total SNPs: 220
Non-coding: 83 | Synonymous: 69 | Nonsynonymous: 66 | Stop Codon: 2
Protein Length: 1173 | Molecular Weight (kDa): 137.527
UniProt ID(s): Q8IEM5
PDB ID(s): None
Isoelectric Point: 9.47
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000086 | NUDIX hydrolase domain |
| InterPro | IPR007722 | mRNA decapping protein 2, Box A domain |
| InterPro | IPR015797 | NUDIX hydrolase-like domain superfamily |
| InterPro | IPR020084 | NUDIX hydrolase, conserved site |
| InterPro | IPR036189 | mRNA decapping protein 2, Box A domain superfamily |
| PFam | PF00293 | NUDIX hydrolase domain |
| PFam | PF05026 | mRNA decapping protein 2, Box A domain |
| Superfamily | SSF140586 | mRNA decapping protein 2, Box A domain superfamily |
| Superfamily | SSF55811 | NUDIX hydrolase-like domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 37309887 | A unique mRNA decapping complex in trypanosomes | Kramer S, Karolak NK, ..., Zoltner M | 10.1093/nar/gkad497 |