PF3D7_1309000

Genome location: Pf3D7_13_v3:415,450..417,742(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.12	0.94
Trophozoite	expressed	0.14	0.91
Schizont	expressed	0.02	0.99
Gametocyte	expressed	0.10	0.94

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1309000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.131 | MFS: -2.813 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEM4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103111

Most Similar Human Ortholog: Q53GS7

TM-align score: 0.66 | RMSD: 3.30

Seq Identity: 0.12 | Length: 276 / 360

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000119392	GLE1 RNA export mediator

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	24	13	33
disruptive	1	27	16	46
missense	1	26	14	43

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	13	48	25	28
disruptive	8	74	50	118
missense	6	62	37	69

PlasmoDB Total SNPs: 161

Non-coding: 144 | Synonymous: 12 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 360 | Molecular Weight (kDa): 42.316

UniProt ID(s): Q8IEM4

PDB ID(s): None

Isoelectric Point: 8.05

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A