Product Description: protein phosphatase PPM6, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 3.1.3.16 (Protein-serine/threonine phosphatase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005634 | nucleus |
| Component | GO:0008287 | protein serine/threonine phosphatase complex |
| Function | GO:0004724 | magnesium-dependent protein serine/threonine phosphatase activity |
| Function | GO:0004722 | protein serine/threonine phosphatase activity |
| Process | GO:0006468 | protein phosphorylation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.27 | 0.86 |
| Trophozoite | expressed | 0.52 | 0.69 |
| Schizont | expressed | 0.90 | 0.51 |
| Gametocyte | expressed | 0.67 | 0.63 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1309200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -3.092 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1407700)
Modification: Tagged | RMgm-1080
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IEM2
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.1.3.16 | protein-serine/threonine phosphatase | ATPADPUDPAMPGTPUTPUMPNaFEDTAEGTAcAMPNADPH... |
No evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 51 | 23 | 57 |
| disruptive | 24 | 109 | 47 | 119 |
| missense | 20 | 83 | 39 | 89 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 18 | 97 | 26 | 52 |
| disruptive | 67 | 213 | 106 | 240 |
| missense | 43 | 147 | 78 | 123 |
PlasmoDB Total SNPs: 200
Non-coding: 127 | Synonymous: 46 | Nonsynonymous: 27 | Stop Codon: 0
Protein Length: 827 | Molecular Weight (kDa): 96.579
UniProt ID(s): Q8IEM2
PDB ID(s): None
Isoelectric Point: 8.33
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001932 | PPM-type phosphatase domain |
| InterPro | IPR015655 | Protein phosphatase 2C family |
| InterPro | IPR036457 | PPM-type phosphatase domain superfamily |
| PFam | PF00481 | PPM-type phosphatase domain |
| Superfamily | SSF81606 | PPM-type phosphatase domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 25011111 | Genome-wide functional analysis of Plasmodium protein phosphatases reveals keyregulators of parasite development and differentiation. | Guttery DS, Poulin B, ..., Tewari R | 10.1016/j.chom.2014.05.020 |
| 35083211 | Functional Characterization of 17 Protein Serine/Threonine Phosphatases inToxoplasma gondii Using CRISPR-Cas9 System | Liang QL, Nie LB, ..., Wang JL | 10.3389/fcell.2021.738794 |