PF3D7_1309400

Genome location: Pf3D7_13_v3:431,848..436,382(+)

Genome classification: Core

Function and Localization

Product Description: HORMA domain protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1309400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.521 | #Insertions: 2

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1407900)

• Relative Growth Rate: 0.94 ± 0.13
• Confidence: 5.40

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1407900)

Modification: Disrupted | RMgm-3768

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEM0

"Best" AlphaFill ligand hit: No AlphaFill hits

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103312

Most Similar Human Ortholog: X6R751

TM-align score: 0.71 | RMSD: 2.24

Seq Identity: 0.31 | Length: 147 / 1327

All Human Orthologs (OrthoMCL):

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

Any inclusion in genotype call

PlasmoDB Total SNPs: 442

Non-coding: 88 | Synonymous: 155 | Nonsynonymous: 198 | Stop Codon: 1

Protein Information

Protein Length: 1327 | Molecular Weight (kDa): 158.123

UniProt ID(s): Q8IEM0

PDB ID(s): None

Isoelectric Point: 6.21

Protein Domain Annotations: