PF3D7_1309500 (GAR1)

Genome location: Pf3D7_13_v3:436,154..437,809(-)

Genome classification: Core

Function and Localization

Product Description: H/ACA ribonucleoprotein complex subunit 1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0031429	box H/ACA snoRNP complex
Component	GO:0005634	nucleus
Function	GO:0034513	box H/ACA snoRNA binding
Process	GO:0009451	RNA modification
Process	GO:0000454	snoRNA guided rRNA pseudouridine synthesis

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.48	0.77
Trophozoite	expressed	0.50	0.70
Schizont	expressed	0.08	0.95
Gametocyte	expressed	0.48	0.72

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1309500

Resistome Missense Mutations: N130Y

Resistome Compounds with Missense Mutations: PS-3

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.129 | MFS: -3.568 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1408000)

Relative Growth Rate: 0.08 ± 0.15
Confidence: 5.19

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I700

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102146

Most Similar Human Ortholog: Q9NY12

TM-align score: 0.48 | RMSD: 2.66

Seq Identity: 0.43 | Length: 111 / 209

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000109534	GAR1 ribonucleoprotein

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	8	4	5	16
disruptive	9	33	16	35
missense	0	21	12	27

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	14	15	15
disruptive	18	57	26	60
missense	3	37	21	46

PlasmoDB Total SNPs: 117

Non-coding: 94 | Synonymous: 12 | Nonsynonymous: 11 | Stop Codon: 0

Protein Information

Protein Length: 209 | Molecular Weight (kDa): 24.981

UniProt ID(s): Q8I700

PDB ID(s): None

Isoelectric Point: 10.89

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR007504	H/ACA ribonucleoprotein complex, subunit Gar1/Naf1
InterPro	IPR009000	Translation protein, beta-barrel domain superfamily
PFam	PF04410	H/ACA ribonucleoprotein complex, subunit Gar1/Naf1
Superfamily	SSF50447	Translation protein, beta-barrel domain superfamily