PF3D7_1309800

Genome location: Pf3D7_13_v3:444,779..446,972(-)

Genome classification: Core

Function and Localization

Product Description: homeobox domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005739	mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	possibly expressed	0.07	0.96
Trophozoite	expressed	0.48	0.72
Schizont	expressed	0.04	0.97
Gametocyte	expressed	0.35	0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1309800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.185 | MFS: -2.873 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1408300)

Relative Growth Rate: 0.10 ± 0.07
Confidence: 6.68

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEL7

"Best" AlphaFill ligand hit: ADP (adenosine-5'-diphosphate, Local RMSD=1.15) with 3BK7 (Global RMSD=14.23)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_139476

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	19	16	18
disruptive	6	24	10	42
missense	6	24	10	38

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	10	34	18	19
disruptive	10	53	26	43
missense	7	50	23	42

PlasmoDB Total SNPs: 114

Non-coding: 89 | Synonymous: 10 | Nonsynonymous: 14 | Stop Codon: 1

Protein Information

Protein Length: 305 | Molecular Weight (kDa): 37.335

UniProt ID(s): Q8IEL7

PDB ID(s): None

Isoelectric Point: 9.26

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR009057	Homeobox-like domain superfamily
PFam	N/A	N/A
Superfamily	SSF46689	Homeobox-like domain superfamily