PF3D7_1309900

Genome location: Pf3D7_13_v3:447,096..448,101(+)

Genome classification: Core

Function and Localization

Product Description: succinate dehydrogenase assembly factor 2, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005739	mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	not expressed	0.14	0.91
Schizont	not expressed	0.01	0.99
Gametocyte	not expressed	0.15	0.91

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1309900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.122 | MFS: -2.878 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1408400)

Relative Growth Rate: 0.15 ± 0.06
Confidence: 7.02

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEL6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102226

Most Similar Human Ortholog: F5GYJ5

TM-align score: 0.50 | RMSD: 2.36

Seq Identity: 0.20 | Length: 88 / 225

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000167985	succinate dehydrogenase complex assembly factor 2
ENSG00000256591	novel transcript

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	11	10	18
disruptive	5	31	26	46
missense	5	31	26	44

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	25	13	13
disruptive	16	78	36	60
missense	11	70	32	39

PlasmoDB Total SNPs: 36

Non-coding: 19 | Synonymous: 6 | Nonsynonymous: 11 | Stop Codon: 0

Protein Information

Protein Length: 225 | Molecular Weight (kDa): 27.112

UniProt ID(s): Q8IEL6

PDB ID(s): None

Isoelectric Point: 9.97

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR005631	Flavinator of succinate dehydrogenase
InterPro	IPR036714	Flavinator of succinate dehydrogenase superfamily
PFam	PF03937	Flavinator of succinate dehydrogenase
Superfamily	SSF109910	Flavinator of succinate dehydrogenase superfamily