About Gene List

PF3D7_1310000 (OSCP)

Genome location: Pf3D7_13_v3:448,789..449,862(+)

Genome classification: Core

Function and Localization

Product Description: ATP synthase subunit O, mitochondrial, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: 3.6.3.14 (Transferred entry: 7.1.2.2)

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005754 mitochondrial proton-transporting ATP synthase, catalytic core
Component GO:0000274 mitochondrial proton-transporting ATP synthase, stator stalk
Component GO:0005739 mitochondrion
Component GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1)
Process GO:0015986 ATP synthesis coupled proton transport
Process GO:0042776 mitochondrial ATP synthesis coupled proton transport
Process GO:1902600 proton transmembrane transport

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite no data N/A N/A
Ring no data 0.04 0.98
Trophozoite no data 0.27 0.83
Schizont no data 0.14 0.91
Gametocyte no data 1.03 0.47

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1310000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.125 | MFS: -3.124 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEL5

"Best" AlphaFill ligand hit: No AlphaFill hits

BRENDA EC Inhibitors:

EC # Name EC Inhibitors
3.6.3.14 H+-transporting two-sector ATPase No BRENDA inhibitors

Orthology to BindingDB Entries:

UniProt Protein Name Species Homology Source BindingDB Ligands
P9WPV3 ATP synthase subunit b-delta OrthoMCL CHEMBL3402635CHEMBL3402627CHEMBL3402631CHEMBL3402629...

Orthology Information

Ortholog Group (OrthoMCL): OG6_101031

Most Similar Human Ortholog: P48047

TM-align score: 0.75 | RMSD: 2.99

Seq Identity: 0.25 | Length: 191 / 253

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000241837 ATP synthase peripheral stalk subunit OSCP
ENSG00000249209 novel protein similar to ATP synthase delta (OSCP) subunit domain

Protein Information

Protein Length: 253 | Molecular Weight (kDa): 30.198

UniProt ID(s): Q8IEL5

PDB ID(s): None

Isoelectric Point: 10

Protein Domain Annotations:

Source Family ID Description
InterPro IPR000711 ATPase, OSCP/delta subunit
InterPro IPR026015 F1F0 ATP synthase OSCP/delta subunit, N-terminal domain superfamily
PFam PF00213 ATPase, OSCP/delta subunit
Superfamily SSF47928 F1F0 ATP synthase OSCP/delta subunit, N-terminal domain superfamily

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 1 10 6 10
disruptive 1 25 14 34
missense 1 24 13 34

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 3 18 9 22
disruptive 6 64 21 57
missense 5 53 19 41

PlasmoDB Total SNPs: 60

Non-coding: 46 | Synonymous: 9 | Nonsynonymous: 4 | Stop Codon: 1

Associated Publications

PMID Title Authors DOI/Link
21984828 ATP synthase complex of Plasmodium falciparum: dimeric assembly in mitochondrialmembranes and resistance to genetic disruption. Nina PB, Morrisey JM, ..., Vaidya AB 10.1074/jbc.M111.290973
34494883 A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. van Esveld SL, Meerstein-Kessel L, ..., Huynen MA 10.1128/mSphere.00614-21
36690622 The mitochondrial inhibitor IF1 binds to the ATP synthase OSCP subunit andprotects cancer cells from apoptosis Galber C, Fabbian S, ..., Giorgio V 10.1038/s41419-023-05572-y
34289894 Role of Plasmodium berghei ookinete surface and oocyst capsule protein, a noveloocyst capsule-associated protein, in ookinete motility Nakayama K, Kimura Y, ..., Ikadai H 10.1186/s13071-021-04868-2