PF3D7_1310300

Genome location: Pf3D7_13_v3:455,314..457,125(-)

Genome classification: Core

Function and Localization

Product Description: zinc finger protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Function	GO:0008270	zinc ion binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.32	0.86
Trophozoite	possibly expressed	0.21	0.87
Schizont	possibly expressed	0.09	0.94
Gametocyte	not expressed	0.16	0.90

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1310300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -3.114 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEL2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_215368

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	11	7	16
disruptive	2	14	8	24
missense	2	14	8	22

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	22	8	24
disruptive	7	38	21	60
missense	4	33	17	44

PlasmoDB Total SNPs: 72

Non-coding: 65 | Synonymous: 5 | Nonsynonymous: 1 | Stop Codon: 1

Protein Information

Protein Length: 247 | Molecular Weight (kDa): 29.346

UniProt ID(s): Q8IEL2

PDB ID(s): None

Isoelectric Point: 8.92

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000306	FYVE zinc finger
InterPro	IPR011011	Zinc finger, FYVE/PHD-type
PFam	PF01363	FYVE zinc finger
Superfamily	SSF57903	Zinc finger, FYVE/PHD-type