PF3D7_1310400

Genome location: Pf3D7_13_v3:457,559..462,935(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.45	0.80
Trophozoite	expressed	0.34	0.80
Schizont	possibly expressed	0.16	0.91
Gametocyte	not expressed	0.33	0.81

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1310400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.662 | #Insertions: 6

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1408900)

Modification: Disrupted | RMgm-3775

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEL1

"Best" AlphaFill ligand hit: ATP (adenosine-5'-triphosphate, Local RMSD=4.61) with 6JWQ (Global RMSD=22.71)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533524

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	24	51	32	66
disruptive	79	228	115	252
missense	31	159	99	199

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	31	92	52	70
disruptive	143	406	151	284
missense	59	298	134	225

PlasmoDB Total SNPs: 388

Non-coding: 205 | Synonymous: 99 | Nonsynonymous: 81 | Stop Codon: 3

Protein Information

Protein Length: 1135 | Molecular Weight (kDa): 132.862

UniProt ID(s): Q8IEL1

PDB ID(s): None

Isoelectric Point: 8.85

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A