Product Description: ER membrane protein complex subunit 7, putative
SignalP Peptide: N/A
# Transmembrane Domains: 2
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0072546 | EMC complex |
| Component | GO:0005783 | endoplasmic reticulum |
| Component | GO:0044228 | host cell surface |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.08 | 0.96 |
| Trophozoite | expressed | 0.19 | 0.88 |
| Schizont | expressed | 0.04 | 0.97 |
| Gametocyte | possibly expressed | 0.12 | 0.92 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1310500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.133 | MFS: -3.083 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1409000)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1409000)
Modification: Disrupted | RMgm-3776
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IEL0
"Best" AlphaFill ligand hit: M7G (7n-methyl-8-hydroguanosine-5'-diphosphate, Local RMSD=2.00) with 5LOP (Global RMSD=15.11)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102814
Most Similar Human Ortholog: Q9NPA0
TM-align score: 0.44 | RMSD: 2.77
Seq Identity: 0.17 | Length: 103 / 205
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000134153 | ER membrane protein complex subunit 7 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 10 | 7 | 14 |
| disruptive | 8 | 16 | 11 | 43 |
| missense | 8 | 15 | 8 | 33 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 29 | 9 | 9 |
| disruptive | 17 | 44 | 34 | 72 |
| missense | 13 | 30 | 29 | 44 |
PlasmoDB Total SNPs: 49
Non-coding: 34 | Synonymous: 10 | Nonsynonymous: 5 | Stop Codon: 0
Protein Length: 205 | Molecular Weight (kDa): 24.413
UniProt ID(s): Q8IEL0
PDB ID(s): None
Isoelectric Point: 8.73
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR019008 | Domain of unknown function DUF2012 |
| InterPro | IPR039163 | ER membrane protein complex subunit 7 |
| PFam | PF09430 | Domain of unknown function DUF2012 |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 28784333 | Identification of novel parasitophorous vacuole proteins in P. falciparumparasites using BioID. | Khosh-Naucke M, Becker J, ..., Spielmann T | 10.1016/j.ijmm.2017.07.007 |
| 29162636 | Quantitative Proteomic Profiling Reveals Novel Plasmodium falciparum SurfaceAntigens and Possible Vaccine Candidates. | Nilsson Bark SK, Ahmad R, ..., Marti M | 10.1074/mcp.RA117.000076 |
| 26512320 | The ubiquitous and ancient E R membrane protein complex (E MC): tether or not? | Wideman JG | 10.12688/f1000research.6944.2 |