About Gene List

PF3D7_1310700 (PIC5)

Genome location: Pf3D7_13_v3:467,319..469,389(-)

Genome classification: Core

Function and Localization

Product Description: PhIL1-interacting candidate PIC5

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0070258 inner membrane pellicle complex
Component GO:0005634 nucleus
Function GO:0005515 protein binding
Process GO:0044409 entry into host
Process GO:0020014 schizogony

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.84 0.76
Trophozoite expressed 0.11 0.94
Schizont expressed 1.47 0.54
Gametocyte expressed 1.04 0.58

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1310700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.208 | MFS: -1.796 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1409200)

  • Relative Growth Rate: 1.06 ± 0.09
  • Confidence: 6.27

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1409200)

Modification: Disrupted | RMgm-3778

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEK9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532342

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 160

Non-coding: 153 | Synonymous: 5 | Nonsynonymous: 1 | Stop Codon: 1

Protein Information

Protein Length: 143 | Molecular Weight (kDa): 16.526

UniProt ID(s): Q8IEK9

PDB ID(s): None

Isoelectric Point: 3.79

Protein Domain Annotations:

Source Family ID Description
InterPro IPR000504 RNA recognition motif domain
InterPro IPR035979 RNA-binding domain superfamily
PFam PF00076 RNA recognition motif domain
Superfamily SSF54928 RNA-binding domain superfamily

Associated Publications

PMID Title Authors DOI/Link
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
29138437 Photosensitized INA-Labelled protein 1 (PhIL1) is novel component of the innermembrane complex and is required for Plasmodium parasite development. Saini E, Zeeshan M, ..., Tewari R 10.1038/s41598-017-15781-z
30379851 Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. Briquet S, Ourimi A, ..., Vaquero C 10.1371/journal.pone.0205596
33830607 Identification of novel inner membrane complex and apical annuli proteins of themalaria parasite Plasmodium falciparum. Wichers JS, Wunderlich J, ..., Gilberger TW 10.1111/cmi.13341
34324609 Plasmodium falciparum PhIL1-associated complex plays an essential role inmerozoite reorientation and invasion of host erythrocytes. Saini E, Sheokand PK, ..., Malhotra P 10.1371/journal.ppat.1009750