Product Description: PhIL1-interacting candidate PIC5
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:0070258 | inner membrane pellicle complex |
Component | GO:0005634 | nucleus |
Function | GO:0005515 | protein binding |
Process | GO:0044409 | entry into host |
Process | GO:0020014 | schizogony |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | expressed | N/A | N/A |
Ring | expressed | 0.84 | 0.76 |
Trophozoite | expressed | 0.11 | 0.94 |
Schizont | expressed | 1.47 | 0.54 |
Gametocyte | expressed | 1.04 | 0.58 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1310700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.208 | MFS: -1.796 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1409200)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1409200)
Modification: Disrupted | RMgm-3778
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IEK9
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 160
Non-coding: 153 | Synonymous: 5 | Nonsynonymous: 1 | Stop Codon: 1
Protein Length: 143 | Molecular Weight (kDa): 16.526
UniProt ID(s): Q8IEK9
PDB ID(s): None
Isoelectric Point: 3.79
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR000504 | RNA recognition motif domain |
InterPro | IPR035979 | RNA-binding domain superfamily |
PFam | PF00076 | RNA recognition motif domain |
Superfamily | SSF54928 | RNA-binding domain superfamily |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
29138437 | Photosensitized INA-Labelled protein 1 (PhIL1) is novel component of the innermembrane complex and is required for Plasmodium parasite development. | Saini E, Zeeshan M, ..., Tewari R | 10.1038/s41598-017-15781-z |
30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
33830607 | Identification of novel inner membrane complex and apical annuli proteins of themalaria parasite Plasmodium falciparum. | Wichers JS, Wunderlich J, ..., Gilberger TW | 10.1111/cmi.13341 |
34324609 | Plasmodium falciparum PhIL1-associated complex plays an essential role inmerozoite reorientation and invasion of host erythrocytes. | Saini E, Sheokand PK, ..., Malhotra P | 10.1371/journal.ppat.1009750 |