PF3D7_1310800

Genome location: Pf3D7_13_v3:470,186..475,454(-)

Genome classification: Core

Function and Localization

Product Description: tetratricopeptide repeat protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.32	0.84
Trophozoite	expressed	0.46	0.73
Schizont	expressed	0.08	0.95
Gametocyte	expressed	0.22	0.87

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1310800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.122 | MFS: -2.953 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEK8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101869

Most Similar Human Ortholog: H7C329

TM-align score: 0.66 | RMSD: 2.34

Seq Identity: 0.07 | Length: 59 / 1385

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000018699	tetratricopeptide repeat domain 27

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	21	64	38	78
disruptive	65	190	114	251
missense	43	161	105	218

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	24	130	57	84
disruptive	121	367	181	358
missense	80	311	159	260

PlasmoDB Total SNPs: 289

Non-coding: 106 | Synonymous: 79 | Nonsynonymous: 104 | Stop Codon: 0

Protein Information

Protein Length: 1385 | Molecular Weight (kDa): 164.522

UniProt ID(s): Q8IEK8

PDB ID(s): None

Isoelectric Point: 6.01

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR011990	Tetratricopeptide-like helical domain superfamily
InterPro	IPR019734	Tetratricopeptide repeat
PFam	PF13181	Tetratricopeptide repeat
Superfamily	SSF48452	Tetratricopeptide-like helical domain superfamily