PF3D7_1310900

Genome location: Pf3D7_13_v3:476,019..477,369(+)

Genome classification: Core

Function and Localization

Product Description: ribosomal protein S15, mitochondrial, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005739	mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.07	0.97
Trophozoite	expressed	0.23	0.86
Schizont	expressed	0.06	0.96
Gametocyte	expressed	0.19	0.88

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1310900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.126 | MFS: -3.06 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1409400)

Relative Growth Rate: 0.24 ± 0.12
Confidence: 5.63

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1409400)

Modification: Disrupted | RMgm-3779

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I6T8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_137157

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	24	10	18
disruptive	3	19	7	28
missense	3	17	7	24

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	11	41	6	20
disruptive	8	37	21	49
missense	5	31	19	43

PlasmoDB Total SNPs: 64

Non-coding: 52 | Synonymous: 8 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 303 | Molecular Weight (kDa): 35.712

UniProt ID(s): Q8I6T8

PDB ID(s): None

Isoelectric Point: 10.57

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000589	Ribosomal protein S15
InterPro	IPR005290	Ribosomal protein S15, bacterial-type
InterPro	IPR009068	S15/NS1, RNA-binding
PFam	PF00312	Ribosomal protein S15
Superfamily	SSF47060	S15/NS1, RNA-binding