About Gene List

PF3D7_1311000 (ISD11)

Genome location: Pf3D7_13_v3:477,378..478,179(-)

Genome classification: Core

Function and Localization

Product Description: protein ISD11

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: 2.8.1.7 (Cysteine desulfurase)

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:1990221 L-cysteine desulfurase complex
Component GO:0005739 mitochondrion
Function GO:0005515 protein binding
Process GO:0016226 iron-sulfur cluster assembly

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.11 0.94
Trophozoite not expressed 0.10 0.94
Schizont not expressed 0.02 0.99
Gametocyte not expressed 0.14 0.92

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1311000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.12 | MFS: 0 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1409500)

  • Relative Growth Rate: 0.12 ± 0.14
  • Confidence: 5.27

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEK7

"Best" AlphaFill ligand hit: No AlphaFill hits

BRENDA EC Inhibitors:

EC # Name EC Inhibitors
2.8.1.7 cysteine desulfurase NaBH4K2TeO3L-cysteineVinylglycineiodoacetamideD-cycloserinedithiothreitolL-AllylglycineN-ethylmaleimideL-selenocysteineinterferon-gammalipopolysaccharide...

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103491

Most Similar Human Ortholog: C9JY28

TM-align score: 0.89 | RMSD: 1.25

Seq Identity: 0.27 | Length: 67 / 87

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000214113 LYR motif containing 4

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 23

Non-coding: 22 | Synonymous: 1 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 87 | Molecular Weight (kDa): 10.637

UniProt ID(s): Q8IEK7

PDB ID(s): None

Isoelectric Point: 9.66

Protein Domain Annotations:

Source Family ID Description
InterPro IPR008011 Complex 1 LYR protein
PFam PF05347 Complex 1 LYR protein
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
24086138 The suf iron-sulfur cluster synthesis pathway is required for apicoplastmaintenance in malaria parasites. Gisselberg JE, Dellibovi-Ragheb TA, ..., Prigge ST 10.1371/journal.ppat.1003655
34032321 [Fe-S] biogenesis and unusual assembly of the ISC scaffold complex in thePlasmodium falciparum mitochondrion. Mohammad Sadik, Mohammad Afsar, Ramachandran R, Habib S 10.1111/mmi.14735
34494883 A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. van Esveld SL, Meerstein-Kessel L, ..., Huynen MA 10.1128/mSphere.00614-21
34612205 Divergent acyl carrier protein decouples mitochondrial Fe-S cluster biogenesisfrom fatty acid synthesis in malaria parasites Falekun S, Sepulveda J, ..., Sigala PA 10.7554/eLife.71636