Product Description: protein ISD11
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 2.8.1.7 (Cysteine desulfurase)
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:1990221 | L-cysteine desulfurase complex |
Component | GO:0005739 | mitochondrion |
Function | GO:0005515 | protein binding |
Process | GO:0016226 | iron-sulfur cluster assembly |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | not expressed | N/A | N/A |
Ring | not expressed | 0.11 | 0.94 |
Trophozoite | not expressed | 0.10 | 0.94 |
Schizont | not expressed | 0.02 | 0.99 |
Gametocyte | not expressed | 0.14 | 0.92 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1311000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.12 | MFS: 0 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1409500)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IEK7
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
EC # | Name | EC Inhibitors |
---|---|---|
2.8.1.7 | cysteine desulfurase | NaBH4K2TeO3L-cysteineVinylglycineiodoacetamideD-cycloserinedithiothreitolL-AllylglycineN-ethylmaleimideL-selenocysteineinterferon-gammalipopolysaccharide... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103491
Most Similar Human Ortholog: C9JY28
TM-align score: 0.89 | RMSD: 1.25
Seq Identity: 0.27 | Length: 67 / 87
All Human Orthologs (OrthoMCL):
Gene ID | Description |
---|---|
ENSG00000214113 | LYR motif containing 4 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 23
Non-coding: 22 | Synonymous: 1 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 87 | Molecular Weight (kDa): 10.637
UniProt ID(s): Q8IEK7
PDB ID(s): None
Isoelectric Point: 9.66
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR008011 | Complex 1 LYR protein |
PFam | PF05347 | Complex 1 LYR protein |
Superfamily | N/A | N/A |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
24086138 | The suf iron-sulfur cluster synthesis pathway is required for apicoplastmaintenance in malaria parasites. | Gisselberg JE, Dellibovi-Ragheb TA, ..., Prigge ST | 10.1371/journal.ppat.1003655 |
34032321 | [Fe-S] biogenesis and unusual assembly of the ISC scaffold complex in thePlasmodium falciparum mitochondrion. | Mohammad Sadik, Mohammad Afsar, Ramachandran R, Habib S | 10.1111/mmi.14735 |
34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
34612205 | Divergent acyl carrier protein decouples mitochondrial Fe-S cluster biogenesisfrom fatty acid synthesis in malaria parasites | Falekun S, Sepulveda J, ..., Sigala PA | 10.7554/eLife.71636 |