PF3D7_1311100

Genome location: Pf3D7_13_v3:479,314..480,853(+)

Genome classification: Core

Function and Localization

Product Description: meiosis-specific nuclear structural protein 1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.12	0.94
Trophozoite	not expressed	0.04	0.98
Schizont	not expressed	0.03	0.98
Gametocyte	expressed	0.89	0.65

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1311100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.998 | MFS: -1.835 | #Insertions: 2

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1409600)

Relative Growth Rate: 1.02 ± 0.05
Confidence: 7.30

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1409600)

Modification: Disrupted | RMgm-3781

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEK6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104986

Most Similar Human Ortholog: Q8NEH6

TM-align score: 0.32 | RMSD: 5.25

Seq Identity: 0.13 | Length: 206 / 495

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000138587	meiosis specific nuclear structural 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	27	17	24
disruptive	14	48	35	84
missense	13	47	34	73

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	51	26	30
disruptive	27	112	56	108
missense	20	99	47	84

PlasmoDB Total SNPs: 41

Non-coding: 3 | Synonymous: 22 | Nonsynonymous: 16 | Stop Codon: 0

Protein Information

Protein Length: 495 | Molecular Weight (kDa): 61.232

UniProt ID(s): Q8IEK6

PDB ID(s): None

Isoelectric Point: 9.51

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR026504	Meiosis-specific nuclear structural protein 1
InterPro	IPR043597	Trichohyalin-plectin-homology domain
PFam	PF13868	Trichohyalin-plectin-homology domain
Superfamily	N/A	N/A