PF3D7_1311200

Genome location: Pf3D7_13_v3:481,029..483,562(-)

Genome classification: Core

Function and Localization

Product Description: transducin beta-like protein TBL1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus
Component	GO:0071011	precatalytic spliceosome
Process	GO:0008380	RNA splicing

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.15	0.92
Trophozoite	expressed	0.47	0.72
Schizont	expressed	0.12	0.92
Gametocyte	expressed	0.30	0.82

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1311200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.132 | MFS: -3.147 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1409700)

Relative Growth Rate: 0.09 ± 0.18
Confidence: 4.80

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEK5

"Best" AlphaFill ligand hit: SIW (keggin (sta), Local RMSD=0.04) with 6Y7O (Global RMSD=6.99)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103380

Most Similar Human Ortholog: Q2TAY7

TM-align score: 0.63 | RMSD: 3.01

Seq Identity: 0.39 | Length: 345 / 527

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000122692	SMU1 DNA replication regulator and spliceosomal factor

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	29	12	29
disruptive	4	31	18	71
missense	4	30	18	60

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	49	24	38
disruptive	8	73	46	85
missense	7	63	39	68

PlasmoDB Total SNPs: 95

Non-coding: 58 | Synonymous: 31 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 527 | Molecular Weight (kDa): 61.432

UniProt ID(s): Q8IEK5

PDB ID(s): None

Isoelectric Point: 6.62

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001680	WD40 repeat
InterPro	IPR006594	LIS1 homology motif
InterPro	IPR036322	WD40-repeat-containing domain superfamily
PFam	PF00400	WD40 repeat
PFam	PF17814
Superfamily	SSF50978	WD40-repeat-containing domain superfamily