Product Description: ATP synthase subunit gamma, mitochondrial
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 3.6.3.14 (Transferred entry: 7.1.2.2)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0000275 | mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1) |
| Component | GO:0005754 | mitochondrial proton-transporting ATP synthase, catalytic core |
| Component | GO:0005739 | mitochondrion |
| Process | GO:0006754 | ATP biosynthetic process |
| Process | GO:0015986 | ATP synthesis coupled proton transport |
| Process | GO:1902600 | proton transmembrane transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.05 | 0.98 |
| Trophozoite | expressed | 0.26 | 0.83 |
| Schizont | expressed | 0.12 | 0.92 |
| Gametocyte | possibly expressed | 0.30 | 0.82 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1311300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.121 | MFS: -3.033 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1409800)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1409800)
Modification: Disrupted | RMgm-3783
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I6T7
"Best" AlphaFill ligand hit: PIT (piceatannol, Local RMSD=0.28) with 2JJ1 (Global RMSD=1.88)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.6.3.14 | H+-transporting two-sector ATPase | No BRENDA inhibitors |
Orthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| P05631 | ATP synthase subunit gamma, mitochondrial | Bos taurus | HOGENOM, OMA, OrthoDB | CHEMBL11859CHEMBL273900CHEMBL11502BMS-191095... |
| P9WPU9 | ATP synthase epsilon chain/gamma chain/subunit a/subunit alpha/subunit b/subunit b-delta/subunit beta/subunit c | OMA, OrthoMCL | CHEMBL3400982 |
Ortholog Group (OrthoMCL): OG6_100847
Most Similar Human Ortholog: P36542
TM-align score: 0.86 | RMSD: 2.58
Seq Identity: 0.35 | Length: 282 / 311
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000165629 | ATP synthase F1 subunit gamma |
Protein Length: 311 | Molecular Weight (kDa): 35.755
UniProt ID(s): Q8I6T7
PDB ID(s): None
Isoelectric Point: 10.01
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000131 | ATP synthase, F1 complex, gamma subunit |
| InterPro | IPR023632 | ATP synthase, F1 complex, gamma subunit conserved site |
| InterPro | IPR035968 | ATP synthase, F1 complex, gamma subunit superfamily |
| PFam | PF00231 | ATP synthase, F1 complex, gamma subunit |
| Superfamily | SSF52943 | ATP synthase, F1 complex, gamma subunit superfamily |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 21 | 9 | 14 |
| disruptive | 5 | 12 | 7 | 26 |
| missense | 5 | 12 | 7 | 25 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 33 | 10 | 22 |
| disruptive | 9 | 33 | 23 | 77 |
| missense | 9 | 27 | 21 | 49 |
PlasmoDB Total SNPs: 74
Non-coding: 59 | Synonymous: 10 | Nonsynonymous: 5 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 21984828 | ATP synthase complex of Plasmodium falciparum: dimeric assembly in mitochondrialmembranes and resistance to genetic disruption. | Nina PB, Morrisey JM, ..., Vaidya AB | 10.1074/jbc.M111.290973 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |