PF3D7_1311600

Genome location: Pf3D7_13_v3:493,795..497,416(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	possibly expressed	0.43	0.78
Trophozoite	expressed	0.32	0.81
Schizont	expressed	0.57	0.66
Gametocyte	expressed	0.45	0.74

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1311600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.998 | MFS: -2.434 | #Insertions: 1

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1410100)

Relative Growth Rate: 0.10 ± 0.08
Confidence: 6.32

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEK2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532892

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	32	18	40
disruptive	20	84	40	113
missense	17	82	39	101

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	66	25	52
disruptive	33	184	79	192
missense	26	166	66	129

PlasmoDB Total SNPs: 165

Non-coding: 127 | Synonymous: 16 | Nonsynonymous: 21 | Stop Codon: 1

Protein Information

Protein Length: 613 | Molecular Weight (kDa): 72.862

UniProt ID(s): Q8IEK2

PDB ID(s): None

Isoelectric Point: 4.46

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A