Product Description: cytochrome c, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0005758 | mitochondrial intermembrane space |
| Component | GO:0005746 | mitochondrial respirasome |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0009055 | electron transfer activity |
| Process | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen |
| Process | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c |
| Process | GO:0055114 | oxidation-reduction process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.05 | 0.97 |
| Trophozoite | expressed | 0.10 | 0.94 |
| Schizont | expressed | 0.01 | 1.00 |
| Gametocyte | expressed | 0.06 | 0.96 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1311700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.31 | MFS: -2.645 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1410200)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1410200)
Modification: Disrupted | RMgm-3787
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I6T6
"Best" AlphaFill ligand hit: 15P (peg 1500, Local RMSD=0.02) with 7BBT (Global RMSD=3.23)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 1 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 131
Non-coding: 127 | Synonymous: 4 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 159 | Molecular Weight (kDa): 17.964
UniProt ID(s): Q8I6T6
Isoelectric Point: 9.61
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002327 | Cytochrome c, class IA/ IB |
| InterPro | IPR009056 | Cytochrome c-like domain |
| InterPro | IPR036909 | Cytochrome c-like domain superfamily |
| PFam | PF00034 | Cytochrome c-like domain |
| Superfamily | SSF46626 | Cytochrome c-like domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 31631203 | A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. | Das D, Krishnan SR, Roy A, Bulusu G | 10.1039/c9mo00124g |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |