Product Description: malonyl CoA-acyl carrier protein transacylase
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: 2.3.1.39 ([Acyl-carrier-protein] S-malonyltransferase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020011 | apicoplast |
| Function | GO:0004314 | [acyl-carrier-protein] S-malonyltransferase activity |
| Process | GO:0006633 | fatty acid biosynthetic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.02 | 0.99 |
| Trophozoite | not expressed | 0.04 | 0.98 |
| Schizont | not expressed | 0.03 | 0.98 |
| Gametocyte | expressed | 0.17 | 0.89 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1312000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.119 | MFS: -2.88 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1410500)
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1410500)
Modification: Disrupted | RMgm-4604
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I6Z9
"Best" AlphaFill ligand hit: CXS (3-cyclohexyl-1-propylsulfonic acid, Local RMSD=0.06) with 3HJV (Global RMSD=2.99)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 2.3.1.39 | [acyl-carrier-protein] S-malonyltransferase | CoAEDTAMgCl2CaCl2MnCl2NiSO4boldineisoniazidacetyl-CoAmalonyl-CoAiodoacetatereduced CoA... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101327
Most Similar Human Ortholog: Q8IVS2
TM-align score: 0.75 | RMSD: 2.19
Seq Identity: 0.28 | Length: 309 / 403
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000100294 | malonyl-CoA-acyl carrier protein transacylase |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 22 | 17 | 38 |
| disruptive | 9 | 40 | 25 | 51 |
| missense | 9 | 40 | 25 | 49 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 10 | 46 | 15 | 44 |
| disruptive | 15 | 98 | 47 | 111 |
| missense | 13 | 87 | 42 | 71 |
PlasmoDB Total SNPs: 75
Non-coding: 45 | Synonymous: 21 | Nonsynonymous: 9 | Stop Codon: 0
Protein Length: 403 | Molecular Weight (kDa): 46.305
PDB ID(s): None
Isoelectric Point: 8.75
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR014043 | Acyl transferase |
| InterPro | IPR016035 | Acyl transferase/acyl hydrolase/lysophospholipase |
| PFam | PF00698 | Acyl transferase |
| Superfamily | SSF52151 | Acyl transferase/acyl hydrolase/lysophospholipase |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12549938 | The initiating steps of a type II fatty acid synthase in Plasmodium falciparumare catalyzed by pfACP, pfMCAT, and pfKASIII. | Prigge ST, He X, ..., Reynolds KA | 10.1021/bi026847k |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |