PF3D7_1312100

Genome location: Pf3D7_13_v3:512,887..517,603(-)

Genome classification: Core

Function and Localization

Product Description: GYF domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.03	0.98
Trophozoite	expressed	0.32	0.81
Schizont	expressed	0.48	0.72
Gametocyte	expressed	0.41	0.77

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1312100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.727 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1410600)

Modification: Disrupted | RMgm-3791

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEK0

"Best" AlphaFill ligand hit: ORO (orotic acid, Local RMSD=1.36) with 1TV5 (Global RMSD=33.02)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532462

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	10	57	33	80
disruptive	45	234	119	304
missense	36	202	108	259

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	22	123	47	98
disruptive	97	482	176	377
missense	64	403	152	283

PlasmoDB Total SNPs: 206

Non-coding: 71 | Synonymous: 83 | Nonsynonymous: 52 | Stop Codon: 0

Protein Information

Protein Length: 1333 | Molecular Weight (kDa): 159.297

UniProt ID(s): Q8IEK0

PDB ID(s): None

Isoelectric Point: 8.21

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR003169	GYF domain
InterPro	IPR035445	GYF-like domain superfamily
PFam	PF02213	GYF domain
Superfamily	SSF55277	GYF-like domain superfamily

PMID	Title	Authors	DOI/Link
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104
23181666	Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum.	Oehring SC, Woodcroft BJ, ..., Voss TS	10.1186/gb-2012-13-11-r108