PF3D7_1312200

Genome location: Pf3D7_13_v3:517,915..519,387(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.04	0.98
Trophozoite	not expressed	0.33	0.80
Schizont	not expressed	0.21	0.85
Gametocyte	not expressed	0.21	0.87

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1312200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.223 | MFS: -3.427 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1410700)

Relative Growth Rate: 0.08 ± 0.04
Confidence: 7.84

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEJ9

"Best" AlphaFill ligand hit: NHE (2-[n-cyclohexylamino]ethane sulfonic acid, Local RMSD=0.15) with 6EAF (Global RMSD=20.71)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_146107

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	15	5	15
disruptive	4	23	12	46
missense	4	22	11	44

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	33	4	19
disruptive	8	54	39	75
missense	7	48	36	58

PlasmoDB Total SNPs: 65

Non-coding: 49 | Synonymous: 10 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 293 | Molecular Weight (kDa): 34.978

UniProt ID(s): Q8IEJ9

PDB ID(s): None

Isoelectric Point: 9.58

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A