About Gene List

PF3D7_1312300

Genome location: Pf3D7_13_v3:519,563..520,735(-)

Genome classification: Core

Function and Localization

Product Description: ribosomal protein S35, mitochondrial, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005739 mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.03 0.98
Trophozoite expressed 0.24 0.85
Schizont expressed 0.06 0.96
Gametocyte expressed 0.24 0.86

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1312300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.147 | MFS: -2.687 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEJ8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_139428

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 12 9 24
disruptive 3 31 14 50
missense 3 31 13 45

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 3 36 15 25
disruptive 8 63 38 61
missense 6 54 35 50

PlasmoDB Total SNPs: 16

Non-coding: 8 | Synonymous: 4 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 280 | Molecular Weight (kDa): 33.797

UniProt ID(s): Q8IEJ8

PDB ID(s): None

Isoelectric Point: 10.36

Protein Domain Annotations:

Source Family ID Description
InterPro IPR019349 Ribosomal protein S24/S35, mitochondrial, conserved domain
PFam PF10213 Ribosomal protein S24/S35, mitochondrial, conserved domain
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
31339607 Identification of the Toxoplasma gondii mitochondrial ribosome, andcharacterisation of a protein essential for mitochondrial translation. Lacombe A, Maclean AE, ..., Sheiner L 10.1111/mmi.14357
34494883 A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. van Esveld SL, Meerstein-Kessel L, ..., Huynen MA 10.1128/mSphere.00614-21