About Gene List

PF3D7_1312450 (ARA1)

Genome location: Pf3D7_13_v3:525,028..525,219(-)

Genome classification: Core

Function and Localization

Product Description: apical ring associated protein 1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020031 polar ring of apical complex

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite no data N/A N/A
Ring no data 0.01 0.99
Trophozoite no data 0.00 1.00
Schizont no data 0.01 0.99
Gametocyte no data 0.11 0.93

More info:

Resistome Mutations

No corresponding Pf3D7v3 gene ID in resistome database

Essentiality (ABS)

Zhang Phenotype: N/A

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not tested (Pb ortholog: PY17X_1412750)

Modification: Disrupted | RMgm-5287

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A146M158

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532580

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 2 6 7
disruptive 8 16 3 6
missense 8 16 3 6

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 2 13 4 5
disruptive 12 19 8 13
missense 12 17 7 11

PlasmoDB Total SNPs: 10

Non-coding: 0 | Synonymous: 2 | Nonsynonymous: 8 | Stop Codon: 0

Protein Information

Protein Length: 63 | Molecular Weight (kDa): 6.834

UniProt ID(s): A0A146M158

PDB ID(s): None

Isoelectric Point: 9.73

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
26018192 Genome-Wide Identification of the Target Genes of AP2-O, a Plasmodium AP2-FamilyTranscription Factor. Kaneko I, Iwanaga S, ..., Yuda M 10.1371/journal.ppat.1004905
33845171 High-yield production of (R)-acetoin in Saccharomyces cerevisiae by deletinggenes for NAD(P)H-dependent ketone reductases producing meso-2,3-butanediol and2,3-dimethylglycerate Bae SJ, Kim S, ..., Hahn JS 10.1016/j.ymben.2021.04.001
37449952 Understanding the role of GRE3 in the erythritol biosynthesis pathway inSaccharomyces uvarum and its implication in osmoregulation and redox homeostasis Albillos-Arenal S, Minebois R, Querol A, Barrio E 10.1111/1751-7915.14313
27400981 alpha,beta-Dicarbonyl reduction is mediated by the Saccharomyces Old Yellow Enzyme van Bergen B, Cyr N, ..., Jardim A 10.1093/femsyr/fow059