PF3D7_1312700

Genome location: Pf3D7_13_v3:532,136..534,965(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.17	0.92
Trophozoite	expressed	0.96	0.52
Schizont	possibly expressed	0.09	0.95
Gametocyte	expressed	0.78	0.61

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1312700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.973 | MFS: -3.124 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEJ5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533116

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	24	21	33
disruptive	18	59	24	95
missense	15	48	19	74

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	54	19	34
disruptive	38	116	54	130
missense	25	82	46	99

PlasmoDB Total SNPs: 86

Non-coding: 48 | Synonymous: 19 | Nonsynonymous: 19 | Stop Codon: 0

Protein Information

Protein Length: 562 | Molecular Weight (kDa): 66.947

UniProt ID(s): Q8IEJ5

PDB ID(s): None

Isoelectric Point: 6.7

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR017996	Major royal jelly protein/protein yellow
PFam	N/A	N/A
Superfamily	N/A	N/A