Product Description: protein AAP2
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0045177 | apical part of cell |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.25 | 0.88 |
| Trophozoite | not expressed | 1.04 | 0.50 |
| Schizont | possibly expressed | 2.50 | 0.12 |
| Gametocyte | expressed | 1.54 | 0.33 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1312800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -0.057 | #Insertions: 5
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1411200)
Modification: Disrupted | RMgm-3795
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IEJ4
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 24 | 130 | 81 | 160 |
| disruptive | 104 | 468 | 253 | 590 |
| missense | 70 | 366 | 219 | 493 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 46 | 258 | 92 | 181 |
| disruptive | 216 | 925 | 376 | 714 |
| missense | 131 | 727 | 325 | 533 |
PlasmoDB Total SNPs: 379
Non-coding: 151 | Synonymous: 102 | Nonsynonymous: 126 | Stop Codon: 0
Protein Length: 2361 | Molecular Weight (kDa): 277.697
UniProt ID(s): Q8IEJ4
PDB ID(s): None
Isoelectric Point: 7.92
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 33830607 | Identification of novel inner membrane complex and apical annuli proteins of themalaria parasite Plasmodium falciparum. | Wichers JS, Wunderlich J, ..., Gilberger TW | 10.1111/cmi.13341 |
| 38161486 | Antioxidant Activity of Auricularia auricula Polysaccharides with DifferentMolecular Weights and Cytotoxicity Difference of Polysaccharides Regulated CaOxto HK-2 Cells | Heng BL, Wu FY, Liu JH, Ouyang JM | 10.1155/2023/9968886 |
| 35684579 | Structural Characterization and In-Vitro Antioxidant and ImmunomodulatoryActivities of Polysaccharide Fractions Isolated from Artemisia annua L | Zhang L, Reddy N, Khoo CS, Koyyalamudi SR | 10.3390/molecules27113643 |
| 24750922 | Immuno-enhancing activity of sulfated Auricularia auricula polysaccharides | Nguyen TL, Wang D, ..., Dang BK | 10.1016/j.carbpol.2012.03.082 |
| 22939338 | In vitro antiviral activity of sulfated Auricularia auricula polysaccharides | Nguyen TL, Chen J, ..., Dang BK | 10.1016/j.carbpol.2012.06.060 |
| 26123819 | Effect of ultrasonic treatment on immunological activities of polysaccharidesfrom adlay | Yao Y, Zhu Y, Gao Y, Ren G | 10.1016/j.ijbiomac.2015.06.033 |
| 27506886 | Antioxidant activity in vitro and in vivo of the polysaccharides from differentvarieties of Auricularia auricula | Xu S, Zhang Y, Jiang K | 10.1039/c6fo00686h |