Product Description: eukaryotic translation initation factor 4 gamma
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Function | GO:0005515 | protein binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.23 | 0.47 |
| Trophozoite | expressed | 1.49 | 0.31 |
| Schizont | expressed | 1.57 | 0.28 |
| Gametocyte | expressed | 1.06 | 0.46 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1312900
Resistome Missense Mutations: H527N
Resistome Compounds with Missense Mutations: AN13762, AN13956
Resistome # Samples with Disruptive Mutations: 7 (7 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -0.829 | #Insertions: 4
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1411300)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H5B1
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| Q04637 | Eukaryotic translation initiation factor 4 gamma 1 | Homo sapiens | OrthoDB | cid_646096cid_646406med.21724, Compound 153MLS000041608... |
Protein Length: 1255 | Molecular Weight (kDa): 146.647
UniProt ID(s): A2ICF4, A2ICF5, A3FJ63, C0H5B1, P04931
PDB ID(s): None
Isoelectric Point: 8.88
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR003890 | MIF4G-like, type 3 |
| InterPro | IPR016024 | Armadillo-type fold |
| PFam | N/A | N/A |
| Superfamily | SSF48371 | Armadillo-type fold |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 67 | 33 | 88 |
| disruptive | 39 | 174 | 101 | 216 |
| missense | 24 | 129 | 85 | 167 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 17 | 142 | 57 | 85 |
| disruptive | 87 | 452 | 192 | 432 |
| missense | 51 | 322 | 145 | 231 |
PlasmoDB Total SNPs: 237
Non-coding: 144 | Synonymous: 53 | Nonsynonymous: 40 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 19751846 | Isolation and functional characterization of eIF4F components and poly(A)-bindingprotein from Plasmodium falciparum. | Tuteja R, Pradhan A | 10.1016/j.parint.2009.09.001 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 38272944 | Structural analysis of the Trypanosoma brucei EIF4E6/EIF4G5 complex revealsdetails of the interaction between unusual eIF4F subunits | Ferras Penteado R, Santana da Silva R, ..., Gomes Guimaraes B | 10.1038/s41598-024-52364-1 |
| 37994298 | RRM1 and PAB domains of translation initiation factor eIF4G (Tif4631p) play acrucial role in the nuclear degradation of export-defective mRNAs inSaccharomyces cerevisiae | Saha U, Gaine R, ..., Das B | 10.1111/febs.17016 |
| 38018538 | Architecture, domain organization, and functional signatures of trypanosomatidkeIF4A1s and Plasmodium peIF4A1s suggest conserved functions | Dadwal A, DAS S | https://pubmed.ncbi.nlm.nih.gov/38018538/ |