PF3D7_1313100

Genome location: Pf3D7_13_v3:556,285..565,251(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.05	0.98
Trophozoite	not expressed	0.13	0.93
Schizont	not expressed	0.13	0.93
Gametocyte	not expressed	0.31	0.84

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1313100

Resistome Missense Mutations: N2553I

Resistome Compounds with Missense Mutations: BRD1095

Resistome # Samples with Disruptive Mutations: 2 (2 missense, 2 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.589 | #Insertions: 9

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533587

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	27	138	101	206
disruptive	108	418	270	695
missense	69	370	245	611

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	45	313	141	238
disruptive	233	955	435	950
missense	142	800	377	718

PlasmoDB Total SNPs: 231

Non-coding: 13 | Synonymous: 115 | Nonsynonymous: 103 | Stop Codon: 0

Protein Information

Protein Length: 2918 | Molecular Weight (kDa): 347.827

UniProt ID(s): Q8IEI2

PDB ID(s): None

Isoelectric Point: 9.81

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A