PF3D7_1313300

Genome location: Pf3D7_13_v3:568,510..569,749(+)

Genome classification: Core

Function and Localization

Product Description: peptidyl-prolyl cis-trans isomerase, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: 5.2.1.8 (Peptidylprolyl isomerase)

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005739	mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	not expressed	0.05	0.97
Trophozoite	possibly expressed	0.14	0.91
Schizont	possibly expressed	0.07	0.95
Gametocyte	expressed	0.40	0.76

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1313300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 1.994 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H5B2

"Best" AlphaFill ligand hit: PGO (s-1,2-propanediol, Local RMSD=0.03) with 4MSP (Global RMSD=9.27)

BRENDA EC Inhibitors:

EC #	Name	EC Inhibitors
5.2.1.8	peptidylprolyl isomerase	ATPNEMSDSPCMBFK506QAEGPKAla-ProjugloneSer-ProGPI-1046RNase T1Rapamycin...

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_121695

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	16	11	12
disruptive	1	25	10	34
missense	1	25	10	29

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	34	8	15
disruptive	8	56	29	57
missense	4	46	25	46

PlasmoDB Total SNPs: 74

Non-coding: 50 | Synonymous: 19 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 213 | Molecular Weight (kDa): 25.611

UniProt ID(s): C0H5B2

PDB ID(s): None

Isoelectric Point: 10.03

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001179	FKBP-type peptidyl-prolyl cis-trans isomerase domain
PFam	PF00254	FKBP-type peptidyl-prolyl cis-trans isomerase domain
Superfamily	SSF54534	N/A