PF3D7_1313500

Genome location: Pf3D7_13_v3:573,169..578,639(-)

Genome classification: Core

Function and Localization

Product Description: TMEM238 domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 14

EC Numbers: None

Curated GO (PlasmoDB):

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1313500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.19 | MFS: -2.723 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEH8

"Best" AlphaFill ligand hit: No AlphaFill hits

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_105151

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

Any inclusion in genotype call

PlasmoDB Total SNPs: 201

Non-coding: 43 | Synonymous: 71 | Nonsynonymous: 85 | Stop Codon: 2

Protein Information

Protein Length: 1737 | Molecular Weight (kDa): 209.075

UniProt ID(s): Q8IEH8

PDB ID(s): None

Isoelectric Point: 7.34

Protein Domain Annotations: