PF3D7_1313600

Genome location: Pf3D7_13_v3:578,990..585,877(-)

Genome classification: Core

Function and Localization

Product Description: Clu domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.05	0.97
Trophozoite	not expressed	0.06	0.96
Schizont	possibly expressed	1.30	0.46
Gametocyte	not expressed	0.43	0.76

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1313600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.999 | MFS: -0.528 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEH7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533301

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	14	88	43	115
disruptive	41	263	145	336
missense	35	252	137	313

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	22	177	74	126
disruptive	99	508	258	475
missense	76	458	229	378

PlasmoDB Total SNPs: 192

Non-coding: 55 | Synonymous: 65 | Nonsynonymous: 72 | Stop Codon: 0

Protein Information

Protein Length: 2029 | Molecular Weight (kDa): 240.595

UniProt ID(s): Q8IEH7

PDB ID(s): None

Isoelectric Point: 8.87

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR011990	Tetratricopeptide-like helical domain superfamily
InterPro	IPR019734	Tetratricopeptide repeat
PFam	N/A	N/A
Superfamily	SSF48452	Tetratricopeptide-like helical domain superfamily