PF3D7_1313800

Genome location: Pf3D7_13_v3:588,141..599,917(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 8

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	2.09	0.23
Trophozoite	expressed	1.17	0.42
Schizont	expressed	1.28	0.41
Gametocyte	not expressed	0.80	0.59

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1313800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.525 | #Insertions: 10

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533169

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	24	166	105	244
disruptive	141	403	270	550
missense	103	372	244	499

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	49	330	148	255
disruptive	241	837	377	761
missense	165	712	338	617

PlasmoDB Total SNPs: 379

Non-coding: 60 | Synonymous: 147 | Nonsynonymous: 172 | Stop Codon: 0

Protein Information

Protein Length: 3411 | Molecular Weight (kDa): 408.841

UniProt ID(s): C0H5B3

PDB ID(s): None

Isoelectric Point: 9.16

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR016024	Armadillo-type fold
PFam	N/A	N/A
Superfamily	SSF48371	Armadillo-type fold