PF3D7_1313900

Genome location: Pf3D7_13_v3:600,666..602,194(-)

Genome classification: Core

Function and Localization

Product Description: ankyrin-repeat protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.23	0.89
Trophozoite	no data	0.59	0.66
Schizont	no data	0.13	0.91
Gametocyte	no data	0.65	0.63

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1313900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.196 | #Insertions: 11

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1412300)

Relative Growth Rate: 1.04 ± 0.11
Confidence: 5.85

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1412300)

Modification: Disrupted | RMgm-3799

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H5B4

"Best" AlphaFill ligand hit: COA (coenzyme a, Local RMSD=0.01) with 3Q9N (Global RMSD=1.35)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_165304

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	17	7	29
disruptive	7	39	26	53
missense	6	38	26	52

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	36	19	35
disruptive	17	85	47	90
missense	14	77	42	72

PlasmoDB Total SNPs: 36

Non-coding: 14 | Synonymous: 10 | Nonsynonymous: 12 | Stop Codon: 0

Protein Information

Protein Length: 400 | Molecular Weight (kDa): 47.236

UniProt ID(s): C0H5B4

PDB ID(s): None

Isoelectric Point: 8.31

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR002110	Ankyrin repeat
InterPro	IPR020683	Ankyrin repeat-containing domain
InterPro	IPR036770	Ankyrin repeat-containing domain superfamily
PFam	PF12796	Ankyrin repeat-containing domain
Superfamily	SSF48403	Ankyrin repeat-containing domain superfamily