PF3D7_1314000

Genome location: Pf3D7_13_v3:602,446..606,612(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005739	mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.05	0.98
Trophozoite	possibly expressed	0.33	0.79
Schizont	expressed	0.09	0.94
Gametocyte	possibly expressed	0.39	0.77

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1314000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.126 | MFS: -3.043 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1412400)

Relative Growth Rate: 0.01 ± 0.04
Confidence: 7.99

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEH4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532746

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	9	62	32	90
disruptive	34	144	84	229
missense	28	137	79	210

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	17	112	49	92
disruptive	59	304	145	326
missense	45	268	127	244

PlasmoDB Total SNPs: 162

Non-coding: 82 | Synonymous: 42 | Nonsynonymous: 37 | Stop Codon: 1

Protein Information

Protein Length: 1205 | Molecular Weight (kDa): 143.592

UniProt ID(s): Q8IEH4

PDB ID(s): None

Isoelectric Point: 9.32

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A