Product Description: conserved Plasmodium protein, unknown function
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB): None
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | not expressed | N/A | N/A |
Ring | expressed | 0.13 | 0.93 |
Trophozoite | expressed | 0.39 | 0.76 |
Schizont | possibly expressed | 0.04 | 0.97 |
Gametocyte | expressed | 0.23 | 0.86 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1314100
Resistome Missense Mutations: S425F
Resistome Compounds with Missense Mutations: MMV665794
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.138 | MFS: -3.16 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1412500)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IEH3
"Best" AlphaFill ligand hit: SAM (s-adenosylmethionine, Local RMSD=1.66) with 2PLW (Global RMSD=15.09)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 6 | 39 | 20 | 47 |
disruptive | 16 | 84 | 46 | 144 |
missense | 15 | 79 | 46 | 134 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 9 | 70 | 28 | 64 |
disruptive | 37 | 185 | 102 | 163 |
missense | 33 | 166 | 93 | 131 |
PlasmoDB Total SNPs: 146
Non-coding: 93 | Synonymous: 35 | Nonsynonymous: 18 | Stop Codon: 0
Protein Length: 752 | Molecular Weight (kDa): 89.233
UniProt ID(s): Q8IEH3
PDB ID(s): None
Isoelectric Point: 6.83
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | N/A | N/A |
PFam | N/A | N/A |
Superfamily | N/A | N/A |
No associated publications