About Gene List

PF3D7_1314100

Genome location: Pf3D7_13_v3:606,945..610,544(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.13 0.93
Trophozoite expressed 0.39 0.76
Schizont possibly expressed 0.04 0.97
Gametocyte expressed 0.23 0.86

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1314100

Resistome Missense Mutations: S425F

Resistome Compounds with Missense Mutations: MMV665794

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.138 | MFS: -3.16 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1412500)

  • Relative Growth Rate: 0.13 ± 0.18
  • Confidence: 4.84

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEH3

"Best" AlphaFill ligand hit: SAM (s-adenosylmethionine, Local RMSD=1.66) with 2PLW (Global RMSD=15.09)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532828

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 6 39 20 47
disruptive 16 84 46 144
missense 15 79 46 134

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 9 70 28 64
disruptive 37 185 102 163
missense 33 166 93 131

PlasmoDB Total SNPs: 146

Non-coding: 93 | Synonymous: 35 | Nonsynonymous: 18 | Stop Codon: 0

Protein Information

Protein Length: 752 | Molecular Weight (kDa): 89.233

UniProt ID(s): Q8IEH3

PDB ID(s): None

Isoelectric Point: 6.83

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

No associated publications