PF3D7_1314300

Genome location: Pf3D7_13_v3:618,973..620,881(-)

Genome classification: Core

Function and Localization

Product Description: MACRO domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: 3.5.1.98 (Histone deacetylase)

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005739	mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.05	0.98
Trophozoite	expressed	0.33	0.79
Schizont	expressed	0.04	0.97
Gametocyte	expressed	0.18	0.89

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1314300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.135 | MFS: -2.817 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEH1

"Best" AlphaFill ligand hit: ADP (adenosine-5'-diphosphate, Local RMSD=3.36) with 5L9Q (Global RMSD=6.92)

BRENDA EC Inhibitors:

EC #	Name	EC Inhibitors
3.5.1.98	histone deacetylase	EDTAPAOASAHAFOXPFK228MCP30shRNAsiRNAMS-275LAQ824MC1575MC1568...

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_143350

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	32	17	37
disruptive	6	32	17	66
missense	6	32	17	54

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	12	56	24	27
disruptive	12	67	40	105
missense	10	62	33	79

PlasmoDB Total SNPs: 57

Non-coding: 16 | Synonymous: 31 | Nonsynonymous: 8 | Stop Codon: 2

Protein Information

Protein Length: 464 | Molecular Weight (kDa): 54.503

UniProt ID(s): Q8IEH1

PDB ID(s): None

Isoelectric Point: 9.79

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR002589	Macro domain
InterPro	IPR043472	Macro domain-like
PFam	PF01661	Macro domain
Superfamily	SSF52949	Macro domain-like