PF3D7_1314500

Genome location: Pf3D7_13_v3:622,348..624,209(-)

Genome classification: Core

Function and Localization

Product Description: transmembrane emp24 domain-containing protein, putative

SignalP Peptide: MIYFKNIVLLSFLLLFFLFGIIQC

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0030134	COPII-coated ER to Golgi transport vesicle
Component	GO:0005794	Golgi apparatus
Component	GO:0005783	endoplasmic reticulum
Component	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
Component	GO:0016020	membrane
Process	GO:0007030	Golgi organization
Process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport
Process	GO:0006886	intracellular protein transport

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.04	0.98
Trophozoite	expressed	0.20	0.87
Schizont	possibly expressed	0.05	0.96
Gametocyte	possibly expressed	0.14	0.92

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1314500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.124 | MFS: -2.961 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1413000)

Relative Growth Rate: 0.95 ± 0.06
Confidence: 6.98

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1413000)

Modification: Disrupted | RMgm-3802

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I6T5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101558

Most Similar Human Ortholog: E7EQ72

TM-align score: 0.55 | RMSD: 3.39

Seq Identity: 0.16 | Length: 112 / 206

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000086598	transmembrane p24 trafficking protein 2

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	7	8	5	11
disruptive	6	18	10	36
missense	6	18	9	33

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	20	15	12
disruptive	11	49	29	58
missense	8	42	23	45

PlasmoDB Total SNPs: 83

Non-coding: 70 | Synonymous: 9 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 206 | Molecular Weight (kDa): 24.443

UniProt ID(s): Q8I6T5

PDB ID(s): None

Isoelectric Point: 6.26

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR009038	GOLD domain
InterPro	IPR015720	TMP21-related
PFam	PF01105	GOLD domain
Superfamily	N/A	N/A