PF3D7_1314700

Genome location: Pf3D7_13_v3:626,197..629,114(-)

Genome classification: Core

Function and Localization

Product Description: pinin/SDK/MemA domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	not expressed	0.09	0.96
Trophozoite	expressed	0.54	0.69
Schizont	expressed	0.14	0.92
Gametocyte	possibly expressed	0.59	0.67

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1314700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.142 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEG8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_127590

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	33	24	30
disruptive	13	100	42	103
missense	8	94	40	90

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	10	59	27	30
disruptive	35	178	74	137
missense	26	157	70	98

PlasmoDB Total SNPs: 164

Non-coding: 82 | Synonymous: 54 | Nonsynonymous: 28 | Stop Codon: 0

Protein Information

Protein Length: 554 | Molecular Weight (kDa): 65.67

UniProt ID(s): Q8IEG8

PDB ID(s): None

Isoelectric Point: 6.05

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR006786	Pinin/SDK/MemA protein
PFam	PF04696	Pinin/SDK/MemA protein
Superfamily	N/A	N/A