PF3D7_1314800

Genome location: Pf3D7_13_v3:629,766..630,444(-)

Genome classification: Core

Function and Localization

Product Description: ubiquitin-like protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Process	GO:0019941	modification-dependent protein catabolic process

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	not expressed	0.01	0.99
Schizont	not expressed	0.01	1.00
Gametocyte	not expressed	0.07	0.96

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1314800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.124 | MFS: -3.047 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1413300)

Relative Growth Rate: 1.02 ± 0.11
Confidence: 5.87

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1413300)

Modification: Disrupted | RMgm-3804

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEG7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_215369

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	8	5	7
disruptive	3	21	11	31
missense	3	20	11	23

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	11	8	11
disruptive	4	51	32	59
missense	3	43	26	32

PlasmoDB Total SNPs: 32

Non-coding: 23 | Synonymous: 6 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 177 | Molecular Weight (kDa): 21.21

UniProt ID(s): Q8IEG7

PDB ID(s): None

Isoelectric Point: 5.64

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000626	Ubiquitin-like domain
InterPro	IPR029071	Ubiquitin-like domain superfamily
PFam	PF00240	Ubiquitin-like domain
Superfamily	SSF54236	Ubiquitin-like domain superfamily