PF3D7_1315000

Genome location: Pf3D7_13_v3:635,796..638,125(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.29	0.85
Trophozoite	expressed	0.19	0.88
Schizont	expressed	0.07	0.95
Gametocyte	not expressed	0.13	0.92

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1315000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.23 | MFS: -3.35 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1413500)

Relative Growth Rate: 0.03 ± 0.06
Confidence: 7.12

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEG5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_158748

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	9	6	11
disruptive	1	16	9	19
missense	1	16	9	18

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	0	21	4	9
disruptive	1	38	11	32
missense	1	31	11	21

PlasmoDB Total SNPs: 109

Non-coding: 97 | Synonymous: 7 | Nonsynonymous: 4 | Stop Codon: 1

Protein Information

Protein Length: 214 | Molecular Weight (kDa): 25.021

UniProt ID(s): Q8IEG5

PDB ID(s): None

Isoelectric Point: 5.27

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A