PF3D7_1315200

Genome location: Pf3D7_13_v3:639,639..643,237(-)

Genome classification: Core

Function and Localization

Product Description: heptatricopeptide repeat-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.03	0.99
Trophozoite	possibly expressed	0.18	0.89
Schizont	not expressed	0.09	0.93
Gametocyte	not expressed	0.21	0.87

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1315200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.133 | MFS: -2.825 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H5B5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_134717

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	47	42	63
disruptive	15	113	82	191
missense	14	109	80	182

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	102	47	84
disruptive	25	273	150	228
missense	22	250	138	187

PlasmoDB Total SNPs: 120

Non-coding: 22 | Synonymous: 67 | Nonsynonymous: 31 | Stop Codon: 0

Protein Information

Protein Length: 1069 | Molecular Weight (kDa): 128.801

UniProt ID(s): C0H5B5

PDB ID(s): None

Isoelectric Point: 8.2

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A