About Gene List

PF3D7_1315300

Genome location: Pf3D7_13_v3:644,504..646,683(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.02 0.99
Trophozoite expressed 0.18 0.88
Schizont expressed 0.61 0.66
Gametocyte expressed 0.47 0.77

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1315300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -3.108 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1413800)

  • Relative Growth Rate: 0.12 ± 0.15
  • Confidence: 5.12

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEG2

"Best" AlphaFill ligand hit: UPG (uridine-5'-diphosphate-glucose, Local RMSD=24.78) with 7MSN (Global RMSD=27.42)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533589

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 4 18 10 30
disruptive 7 40 23 60
missense 5 38 23 58

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 5 38 17 40
disruptive 14 84 57 134
missense 11 74 53 99

PlasmoDB Total SNPs: 74

Non-coding: 56 | Synonymous: 6 | Nonsynonymous: 12 | Stop Codon: 0

Protein Information

Protein Length: 477 | Molecular Weight (kDa): 56.343

UniProt ID(s): Q8IEG2

PDB ID(s): None

Isoelectric Point: 5.6

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108