PF3D7_1315500

Genome location: Pf3D7_13_v3:652,297..654,272(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.04	0.98
Trophozoite	expressed	0.12	0.92
Schizont	expressed	0.13	0.91
Gametocyte	expressed	0.06	0.96

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1315500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.157 | MFS: -2.897 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEF9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_146149

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	9	4	12
disruptive	3	13	10	25
missense	3	12	10	23

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	21	10	17
disruptive	8	31	13	51
missense	6	29	11	35

PlasmoDB Total SNPs: 146

Non-coding: 135 | Synonymous: 5 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 183 | Molecular Weight (kDa): 21.464

UniProt ID(s): Q8IEF9

PDB ID(s): None

Isoelectric Point: 4.76

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A