Product Description: transcription factor MYB1
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Function | GO:0003700 | DNA-binding transcription factor activity |
| Process | GO:0045893 | positive regulation of transcription, DNA-templated |
| Process | GO:0007346 | regulation of mitotic cell cycle |
| Process | GO:0006355 | regulation of transcription, DNA-templated |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.21 | 0.90 |
| Trophozoite | expressed | 0.36 | 0.78 |
| Schizont | expressed | 0.17 | 0.89 |
| Gametocyte | expressed | 0.51 | 0.72 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1315800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.23 | MFS: -2.648 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IEF6
"Best" AlphaFill ligand hit: CLQ (n4-(7-chloro-quinolin-4-yl)-n1,n1-diethyl-pentane-1,4-diamine, Local RMSD=0.12) with 7DI7 (Global RMSD=21.01)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 27 | 7 | 29 |
| disruptive | 1 | 34 | 23 | 67 |
| missense | 1 | 34 | 22 | 62 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 38 | 21 | 27 |
| disruptive | 6 | 102 | 42 | 111 |
| missense | 5 | 84 | 35 | 77 |
PlasmoDB Total SNPs: 82
Non-coding: 49 | Synonymous: 21 | Nonsynonymous: 12 | Stop Codon: 0
Protein Length: 414 | Molecular Weight (kDa): 49.993
PDB ID(s): None
Isoelectric Point: 8.92
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001005 | SANT/Myb domain |
| InterPro | IPR009057 | Homeobox-like domain superfamily |
| PFam | PF13921 | N/A |
| Superfamily | SSF46689 | Homeobox-like domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 15500927 | Characterization of PfMyb1 transcription factor during erythrocytic developmentof 3D7 and F12 Plasmodium falciparum clones. | Boschet C, Gissot M, ..., Vaquero C | 10.1016/j.molbiopara.2004.07.011 |
| 15663925 | PfMyb1, a Plasmodium falciparum transcription factor, is required forintra-erythrocytic growth and controls key genes for cell cycle regulation. | Gissot M, Briquet S, ..., Vaquero C | 10.1016/j.jmb.2004.11.045 |
| 17653272 | Rapid identification of malaria vaccine candidates based on alpha-helical coiledcoil protein motif. | Villard V, Agak GW, ..., Corradin G | 10.1371/journal.pone.0000645 |