PF3D7_1315900

Genome location: Pf3D7_13_v3:662,771..668,049(+)

Genome classification: Core

Function and Localization

Product Description: exportin-T, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Function	GO:0000049	tRNA binding
Process	GO:0006409	tRNA export from nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.40	0.80
Trophozoite	expressed	0.45	0.73
Schizont	expressed	0.17	0.88
Gametocyte	expressed	0.19	0.88

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1315900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.998 | MFS: -2.253 | #Insertions: 3

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1414400)

Relative Growth Rate: 0.81 ± 0.14
Confidence: 5.28

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1414400)

Modification: Disrupted | RMgm-3809

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8Q1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103085

Most Similar Human Ortholog: F8WDU6

TM-align score: 0.82 | RMSD: 2.51

Seq Identity: 0.23 | Length: 190 / 1232

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000184575	exportin for tRNA

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	58	39	77
disruptive	23	77	52	148
missense	19	74	50	133

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	13	115	61	83
disruptive	34	179	90	223
missense	29	157	75	170

PlasmoDB Total SNPs: 203

Non-coding: 131 | Synonymous: 44 | Nonsynonymous: 27 | Stop Codon: 1

Protein Information

Protein Length: 1232 | Molecular Weight (kDa): 142.998

UniProt ID(s): A0A5K1K8Q1

PDB ID(s): None

Isoelectric Point: 5.78

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR013598	Exportin-1/Importin-beta-like
InterPro	IPR016024	Armadillo-type fold
InterPro	IPR040017	Exportin-T
PFam	PF08389	Exportin-1/Importin-beta-like
Superfamily	SSF48371	Armadillo-type fold