Product Description: inositol polyphosphate kinase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 2.7.-.- (Transferring phosphorus-containing groups.);2.7.1.151 (Inositol-polyphosphate multikinase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005634 | nucleus |
| Function | GO:0000828 | inositol hexakisphosphate kinase activity |
| Function | GO:0016301 | kinase activity |
| Process | GO:0032958 | inositol phosphate biosynthetic process |
| Process | GO:0046854 | phosphatidylinositol phosphate biosynthetic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.49 | 0.77 |
| Trophozoite | not expressed | 1.07 | 0.48 |
| Schizont | not expressed | 0.81 | 0.59 |
| Gametocyte | possibly expressed | 1.15 | 0.43 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1316100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.492 | #Insertions: 4
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1414600)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1414600)
Modification: Disrupted | RMgm-3811
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IEF3
"Best" AlphaFill ligand hit: QUE (quercetin, Local RMSD=0.38) with 6M89 (Global RMSD=2.10)
BRENDA EC Inhibitors:
Orthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| Q96PC2 | Inositol hexakisphosphate kinase 3 | OrthoDB, OrthoMCL BLAST | CHEMBL4555782CHEMBL1368139US9903855, Molecule 1CHEMBL5201056... | |
| Q9UHH9 | Inositol hexakisphosphate kinase 2 | OrthoDB | CHEMBL243677Myricetin (Myr)Kaempferol (Kmp)acs.jmedchem.1c00409_ST.789... | |
| Q92551 | Inositol hexakisphosphate kinase 1 | OrthoDB | CHEMBL4459958CHEMBL4563130CHEMBL4555782CHEMBL4555782... |
Ortholog Group (OrthoMCL): OG6_101518
Most Similar Human Ortholog: A0A0U1RRE0
TM-align score: 0.69 | RMSD: 1.58
Seq Identity: 0.34 | Length: 61 / 1601
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000068745 | inositol hexakisphosphate kinase 2 |
| ENSG00000161896 | inositol hexakisphosphate kinase 3 |
| ENSG00000176095 | inositol hexakisphosphate kinase 1 |
Protein Length: 1601 | Molecular Weight (kDa): 192.246
UniProt ID(s): Q8IEF3
PDB ID(s): None
Isoelectric Point: 9.62
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR005522 | Inositol polyphosphate kinase |
| PFam | PF03770 | Inositol polyphosphate kinase |
| Superfamily | SSF56104 | N/A |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 12 | 99 | 59 | 103 |
| disruptive | 55 | 232 | 123 | 294 |
| missense | 38 | 208 | 106 | 259 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 29 | 202 | 74 | 99 |
| disruptive | 107 | 495 | 226 | 455 |
| missense | 68 | 421 | 193 | 344 |
PlasmoDB Total SNPs: 219
Non-coding: 51 | Synonymous: 81 | Nonsynonymous: 84 | Stop Codon: 3
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 33282871 | Sphingolipids and Inositol Phosphates Regulate the Tau Protein PhosphorylationStatus in Humanized Yeast | Randez-Gil F, Bojunga L, ..., Prieto JA | 10.3389/fcell.2020.592159 |
| 18694931 | Regulation of telomere length by fatty acid elongase 3 in yeast. Involvement ofinositol phosphate metabolism and Ku70/80 function | Ponnusamy S, Alderson NL, ..., Ogretmen B | 10.1074/jbc.M802980200 |
| 21538248 | Transcriptional control of genes involved in yeast phospholipid biosynthesis | Wimalarathna R, Tsai CH, Shen CH | 10.1007/s12275-011-1130-1 |
| 22889849 | KCS1 deletion in Saccharomyces cerevisiae leads to a defect in translocation ofautophagic proteins and reduces autophagosome formation | Taylor R Jr, Chen PH, ..., Jin SV | 10.4161/auto.20681 |