Product Description: SAS6-like protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020007 | apical complex |
| Component | GO:0005829 | cytosol |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.00 | 1.00 |
| Trophozoite | not expressed | 0.01 | 1.00 |
| Schizont | not expressed | 0.00 | 1.00 |
| Gametocyte | expressed | 0.07 | 0.96 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1316400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -0.797 | #Insertions: 2
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not tested (Pb ortholog: PY17X_1416600)
Modification: Tagged | RMgm-5291
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A5K1K8S9
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 11 | 9 | 14 |
| disruptive | 4 | 8 | 5 | 17 |
| missense | 4 | 8 | 4 | 15 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 20 | 10 | 14 |
| disruptive | 7 | 19 | 15 | 41 |
| missense | 5 | 15 | 14 | 33 |
PlasmoDB Total SNPs: 80
Non-coding: 63 | Synonymous: 14 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 228 | Molecular Weight (kDa): 26.74
UniProt ID(s): A0A5K1K8S9
PDB ID(s): None
Isoelectric Point: 5.78
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR032396 | Spindle assembly abnormal protein 6, N-terminal |
| PFam | PF16531 | Spindle assembly abnormal protein 6, N-terminal |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 27339728 | SAS6-like protein in Plasmodium indicates that conoid-associated apical complexproteins persist in invasive stages within the mosquito vector. | Wall RJ, Roques M, ..., Tewari R | 10.1038/srep28604 |
| 23687115 | A SAS-6-like protein suggests that the Toxoplasma conoid complex evolved fromflagellar components | de Leon JC, Scheumann N, ..., Morrissette NS | 10.1128/EC.00096-13 |